CHIRAL ART Immobilized type 手性分離管柱(不對稱/鏡相)

YMC Taiwan Co., Ltd.CHIRAL ART Immobilized type 手性分離管柱(不對稱/鏡相)

CHIRAL ART Immobilized type 手性分離管柱(不對稱/鏡相)

產品

CHIRAL ART Immobilized type is an HPLC column with polysaccharide derivatives chiral selector. CHIRAL ART Immobilized type can be used either in normal or reversed-phase modes. CHIRAL ART are suitable for the separation of a wide range of chiral compounds, cis-trans isomers, and geometric isomers. CHIRAL ART are available in HPLC columns and in preparative grades, in large (multi kg) quantities.

Column/Packing material Particle size (µm) Chiral selector USP Code
CHIRAL ART
Amylose-SA		 3, 5, 10, 20 L99
CHIRAL ART
Cellulose-SB		 3, 5, 10, 20 –
CHIRAL ART
Cellulose-SC		 3, 5, 10, 20 L119
CHIRAL ART
Cellulose-SJ		 3, 5, 10, 20 –
CHIRAL ART
Cellulose-SZ		 3, 5, 10, 20 –
Usable mobile phase Normal-phase n-hexane, n-heptane, methanol, ethanol, 2-propanol, acetonitrile, ethyl acetate, tetrahydrofuran, chloroform, t-butyl methyl ether, etc.
Usable mobile phase Reversed-phase acetonitrile, methanol, ethanol, 2-propanol, tetrahydrofuran, water, aqueous buffer, etc.

特點

-Excellent peak shape
-Low column bleeding
-Wide usable pH range
-High solvent versatility

-Excellent peak shape

CHIRAL ART provide good peak shapes for ionic and metal coordination compounds.

Spectrum1
Column 5 μm, 250 X 4.6 mmI.D.
Eluent n-hexane/2-propanol/diethylamine
(80/20/0.1)
Flow rate 1.0 mL/min
Temperature 25°C
Detection UV at 230 nm
Injection 10 μL (0.1 mg/mL)

-Low column bleeding

CHIRAL ART Immobilized type show remarkably reduced background signals under typical gradient conditions. The low column bleeding of these columns provides high sensitivity for LC/MS analysis owing to the very low ion suppression and stable baseline. CHIRAL ART Immobilized type offers excellent robustness for gradient analysis and highly sensitive analysis on LC/MS.

Spectrum2
Gradient test
Column 5 μm, 250 X 4.6 mmI.D.
Eluent A) n-hexane
B) ethanol
2-80%B (0-30 min)
Flow rate 1.0 mL/min
Temperature 25°C
Detection UV at 230 nm

-Wide usable pH range

CHIRAL ART Immobilized type has excellent chemical stability and can be used across a wide pH range. The addition of acid/amine to the mobile phase or the use of buffer solution is an effective tool for improving peak shape and/or resolution.

Photo1
Continuous flow of acid/alkaline solution
Column 5 μm, 50 X 4.6 mmI.D.
Eluent Buffer/methanol (90/10)
Flow rate 1.0 mL/min
【Acidic condition】
Buffer 0.1% H3PO4 (pH 2)
Temperature 40°C
【Basic condition】
Buffer 20 mm NH4HCO3-DEA (pH 9)
Temperature 25°C
Column performance test
Column 5 μm, 50 X 4.6 mmI.D.
Eluent acetonitrile/water (30/70) for SB
methanol/water (70/30) for SJ
Flow rate 1.0 mL/min
Temperature 25°C
Detection UV at 254 nm
Sample Benzoin for SB
1-(1-Naphthyl) ethanol for SJ

-High solvent versatility

On CHIRAL ART Immobilized type, the change in column performance after flushing with each solvent was less than 2%. Thus, these columns have high resistance to various solvents.

Retention rate of initial column performance (after flushing with 1,000CV of each solvent at 40°C)　　*CV＝Column Volume

Amylose-SA Cellulose-SB Cellulose-SJ
α k'(2) α k'(2) α k'(2)
Ethyl acetate 100.3% 101.2% 100.0% 99.1% 99.3% 99.0%
Tetrahydrofuran 100.0% 100.0% 99.3% 98.0% 99.2% 99.7%
Dichloromethane 100.3% 100.6% 101.3% 99.6% 99.6% 98.4%
Column 5 μm, 50 X 4.6 mmI.D.
Eluent n-hexane/2-propanol (95/5)
Flow rate 1.0 mL/min
Temperature 25°C
Sample Benzoin

Application

Compound Packing material Column
N-CBZ-DL-Alanine Amylose-C Neo KBN99S05-2546WT
N-CBZ-DL-Alanine Cellulose-C KCN99S05-2546WT
DL-Aminoglutethimide Cellulose-SJ KSJ99S05-2546WT
Atropine Amylose-C KAN99S05-2546WT
Atropine Cellulose-C KCN99S05-2546WT
Benzoin Amylose-C KAN99S05-2546WT
Benzoin Cellulose-C KCN99S05-2546WT
4-Benzoyloxy-2-azetidinone Cellulose-SZ KSZ99S05-2546WT
1,1′-Binaphthyl-2,2′-diamine Amylose-SA KSA99S05-2546WT
1,1′-Binaphthyl-2,2′-diyl Bis(trifluoromethanesulfonate) Cellulose-SB KSB99S05-2546WT
2,6-Bis(4-isopropyl-2-oxazolin-2-yl)pyridine Cellulose-C KCN99S05-2546WT
1,2-Bis[(2-methoxyphenyl)phenylphosphino]ethane Amylose-C Neo KBN99S05-2546WT
1,2-Bis[(2-methoxyphenyl)phenyl-phosphino]ethane(DIPAMP) Cellulose-SJ KSJ99S05-2546WT
2,6-Bis(4-phenyl-2-oxazolin-2-yl)pyridine Cellulose-C KCN99S05-2546WT
Cetirizine（Levocetirizine） Cellulose-SB KSB99S05-2546WT
Cetirizine（Levocetirizine） Cellulose-C KCN99S05-2546WT
Chloroquine Amylose-SA KSA99S05-2546WT
Citalopram hydrobromide Cellulose-SZ KSZ99S05-2546WT
3,3′-Dibromo-1,1′-bi-2-naphthol Amylose-SA KSA99S05-2546WT
3,3′-Dibromo-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-bi-2-naphthol Amylose-SA KSA99S05-2546WT
2,2′-Dimethoxy-1,1′-binaphthyl Cellulose-SB KSB99S05-2546WT
Donepezil Cellulose-C KCN99S05-2546WT
Donepezil Cellulose-SB KSB99S05-2546WT
Duloxetine Hydrochloride Amylose-C KAN99S05-2546WT
Duloxetine Hydrochloride （USP, Limit of Duloxetine related compound A） Cellulose-C KCN99S05-2546WT
Econazole Cellulose-SZ KSZ99S05-1546WT
Fenoprofen Amylose-SA KSA99S05-2546WT
Flurbiprofen Amylose-SA KSA99S05-2546WT
Hydroxychloroquine Amylose-SA KSA99S05-2546WT
Ibuprofen Cellulose-SB KSB99S05-2546WT
2,2′-Isopropylidenebis(4-phenyl-2-oxazoline) Amylose-C Neo KBN99S05-2546WT
Ketoprofen Cellulose-SC KSC99S05-2546WT
Ketorolac Cellulose-SJ KSJ99S05-2546WT
Lansoprazole Amylose-SA KSA99S05-2546WT
DL-Mandelic acid Amylose-C KAN99S05-2546WT
DL-Mandelic acid Cellulose-C KCN99S05-2546WT
Metoprolol Amylose-C KAN99S05-2546WT
Metoprolol Cellulose-C KCN99S05-2546WT
1-(2-Naphthyl)ethanol Cellulose-SJ KSJ99S05-2546WT
Nelarabine Cellulose-SC KSC99S05-2546WT
Ofloxacin（Levofloxacin） Cellulose-SC KSC99S05-2546WT
Omeprazole Amylose-SA KSA99S03-0503WT
Phenoxybenzamine Cellulose-SJ KSJ99S05-2546WT
N-CBZ-Phenylalanine Cellulose-SC KSC99S05-2546WT
Pindolol Cellulose-SB KSB99S05-2546WT
Pindolol Cellulose-SB KSB99S05-2546WT
Propranolol Cellulose-C KCN99S05-2546WT
Rabeprazole Cellulose-SC KSC99S05-2546WT
Sertraline hydrochloride（EP Enantiomeric purity） Amylose-C KAN99S05-2546WT
trans-Stilbene oxide Amylose-C Neo KBN99S05-2546WT
trans-Stilbene oxide Cellulose-C KCN99S05-2546WT
2,2,2-Trifluoro-1-(9-anthryl)ethanol Cellulose-SJ KSJ99S05-2546WT
Trimebutine Cellulose-SJ KSJ99S05-2546WT
Troger’s base Amylose-SA KSA99S05-2546WT
Valsartan（USP 34th ; Related compounds) Cellulose-C KCN99S05-2546WT
Verapamil Amylose-C KAN99S05-2546WT
Zopiclone Cellulose-SC KSC99S03-1502WT
Warfarin Cellulose-SB KSB99S05-2546WT

Product List

Columns
–Amylose-SA
–Cellulose-SB
–Cellulose-SC
–Cellulose-SJ
–Cellulose-SZ

Guard Columns
–Amylose-SA Cartridge Columns
–Cellulose-SB Cartridge Columns
–Cellulose-SC Cartridge Columns
–Cellulose-SJ Cartridge Columns
–Cellulose-SZ Cartridge Columns
–Cartridge Holder

Packing Materials
–Amylose-SA・Cellulose-SB・Cellulose-SC・Cellulose-SJ

Amylose-SA

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 Product number
3 2.0 X 75 KSA99S03-L502WT
2.0 X 100 KSA99S03-1002WT
2.0 X 150 KSA99S03-1502WT
2.0 X 250 KSA99S03-2502WT
3.0 X 50 KSA99S03-0503WT
3.0 X 75 KSA99S03-L503WT
3.0 X 100 KSA99S03-1003WT
3.0 X 150 KSA99S03-1503WT
3.0 X 250 KSA99S03-2503WT
4.6 X 50 KSA99S03-0546WT
4.6 X 75 KSA99S03-L546WT
4.6 X 100 KSA99S03-1046WT
4.6 X 150 KSA99S03-1546WT
4.6 X 250 KSA99S03-2546WT
5 4.6 X 150 KSA99S05-1546WT
4.6 X 250 KSA99S05-2546WT
10 X 250 KSA99S05-2510WT
20 X 250 KSA99S05-2520WX
30 X 250 KSA99S05-2530WX

Cellulose-SB

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 Product number
3 2.0 X 75 KSB99S03-L502WT
2.0 X 100 KSB99S03-1002WT
2.0 X 150 KSB99S03-1502WT
2.0 X 250 KSB99S03-2502WT
3.0 X 50 KSB99S03-0503WT
3.0 X 75 KSB99S03-L503WT
3.0 X 100 KSB99S03-1003WT
3.0 X 150 KSB99S03-1503WT
3.0 X 250 KSB99S03-2503WT
4.6 X 50 KSB99S03-0546WT
4.6 X 75 KSB99S03-L546WT
4.6 X 100 KSB99S03-1046WT
4.6 X 150 KSB99S03-1546WT
4.6 X 250 KSB99S03-2546WT
5 4.6 X 150 KSB99S05-1546WT
4.6 X 250 KSB99S05-2546WT
10 X 250 KSB99S05-2510WT
20 X 250 KSB99S05-2520WX
30 X 250 KSB99S05-2530WX

Cellulose-SC

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 Product number
3 2.0 X 75 KSC99S03-L502WT
2.0 X 100 KSC99S03-1002WT
2.0 X 150 KSC99S03-1502WT
2.0 X 250 KSC99S03-2502WT
3.0 X 50 KSC99S03-0503WT
3.0 X 75 KSC99S03-L503WT
3.0 X 100 KSC99S03-1003WT
3.0 X 150 KSC99S03-1503WT
3.0 X 250 KSC99S03-2503WT
4.6 X 50 KSC99S03-0546WT
4.6 X 75 KSC99S03-L546WT
4.6 X 100 KSC99S03-1046WT
4.6 X 150 KSC99S03-1546WT
4.6 X 250 KSC99S03-2546WT
5 4.6 X 150 KSC99S05-1546WT
4.6 X 250 KSC99S05-2546WT
10 X 250 KSC99S05-2510WT
20 X 250 KSC99S05-2520WX
30 X 250 KSC99S05-2530WX

Cellulose-SJ

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 Product number
3 2.0 X 75 KSJ99S03-L502WT
2.0 X 100 KSJ99S03-1002WT
2.0 X 150 KSJ99S03-1502WT
2.0 X 250 KSJ99S03-2502WT
3.0 X 50 KSJ99S03-0503WT
3.0 X 75 KSJ99S03-L503WT
3.0 X 100 KSJ99S03-1003WT
3.0 X 150 KSJ99S03-1503WT
3.0 X 250 KSJ99S03-2503WT
4.6 X 50 KSJ99S03-0546WT
4.6 X 75 KSJ99S03-L546WT
4.6 X 100 KSJ99S03-1046WT
4.6 X 150 KSJ99S03-1546WT
4.6 X 250 KSJ99S03-2546WT
5 4.6 X 150 KSJ99S05-1546WT
4.6 X 250 KSJ99S05-2546WT
10 X 250 KSJ99S05-2510WT
20 X 250 KSJ99S05-2520WX
30 X 250 KSJ99S05-2530WX

Cellulose-SZ

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 Product number
3 2.0 X 75 KSZ99S03-L502WT
2.0 X 100 KSZ99S03-1002WT
2.0 X 150 KSZ99S03-1502WT
2.0 X 250 KSZ99S03-2502WT
3.0 X 50 KSZ99S03-0503WT
3.0 X 75 KSZ99S03-L503WT
3.0 X 100 KSZ99S03-1003WT
3.0 X 150 KSZ99S03-1503WT
3.0 X 250 KSZ99S03-2503WT
4.6 X 50 KSZ99S03-0546WT
4.6 X 75 KSZ99S03-L546WT
4.6 X 100 KSZ99S03-1046WT
4.6 X 150 KSZ99S03-1546WT
4.6 X 250 KSZ99S03-2546WT
5 4.6 X 150 KSZ99S05-1546WT
4.6 X 250 KSZ99S05-2546WT
10 X 250 KSZ99S05-2510WT
20 X 250 KSZ99S05-2520WX
30 X 250 KSZ99S05-2530WX

Amylose-SA Cartridge Columns

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 /pack Product Number
3 2.1 X 10 5 KSA99S03-01Q1GC
1 KSA99S03-01Q1GC-1
2.1 X 20 5 KSA99S03-02Q1GC
1 KSA99S03-02Q1GC-1
3.0 X 10 5 KSA99S03-0103GC
1 KSA99S03-0103GC-1
3.0 X 20 5 KSA99S03-0203GC
1 KSA99S03-0203GC-1
4.0 X 10 5 KSA99S03-0104GC
1 KSA99S03-0104GC-1
4.0 X 20 5 KSA99S03-0204GC
1 KSA99S03-0204GC-1
5 4.0 X 10 5 KSA99S05-0104GC
1 KSA99S05-0104GC-1
4.0 X 20 5 KSA99S05-0204GC
1 KSA99S05-0204GC-1
10 X 10 2 KSA99S05-0110CC
20 X 10 2 KSA99S05-0120CCN
30 X 10 2 KSA99S05-0130CCN

*When using it for the first time, please purchase the cartridge holder corresponding to size of column.

Cellulose-SB Cartridge Columns

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 /pack Product Number
3 2.1 X 10 5 KSB99S03-01Q1GC
1 KSB99S03-01Q1GC-1
2.1 X 20 5 KSB99S03-02Q1GC
1 KSB99S03-02Q1GC-1
3.0 X 10 5 KSB99S03-0103GC
1 KSB99S03-0103GC-1
3.0 X 20 5 KSB99S03-0203GC
1 KSB99S03-0203GC-1
4.0 X 10 5 KSB99S03-0104GC
1 KSB99S03-0104GC-1
4.0 X 20 5 KSB99S03-0204GC
1 KSB99S03-0204GC-1
5 4.0 X 10 5 KSB99S05-0104GC
1 KSB99S05-0104GC-1
4.0 X 20 5 KSB99S05-0204GC
1 KSB99S05-0204GC-1
10 X 10 2 KSB99S05-0110CC
20 X 10 2 KSB99S05-0120CCN
30 X 10 2 KSB99S05-0130CCN

*When using it for the first time, please purchase the cartridge holder corresponding to size of column.

Cellulose-SC Cartridge Columns

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 /pack Product Number
3 2.1 X 10 5 KSC99S03-01Q1GC
1 KSC99S03-01Q1GC-1
2.1 X 20 5 KSC99S03-02Q1GC
1 KSC99S03-02Q1GC-1
3.0 X 10 5 KSC99S03-0103GC
1 KSC99S03-0103GC-1
3.0 X 20 5 KSC99S03-0203GC
1 KSC99S03-0203GC-1
4.0 X 10 5 KSC99S03-0104GC
1 KSC99S03-0104GC-1
4.0 X 20 5 KSC99S03-0204GC
1 KSC99S03-0204GC-1
5 4.0 X 10 5 KSC99S05-0104GC
1 KSC99S05-0104GC-1
4.0 X 20 5 KSC99S05-0204GC
1 KSC99S05-0204GC-1
10 X 10 2 KSC99S05-0110CC
20 X 10 2 KSC99S05-0120CCN
30 X 10 2 KSC99S05-0130CCN

*When using it for the first time, please purchase the cartridge holder corresponding to size of column.

Cellulose-SJ Cartridge Columns

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 /pack Product Number
3 2.1 X 10 5 KSJ99S03-01Q1GC
1 KSJ99S03-01Q1GC-1
2.1 X 20 5 KSJ99S03-02Q1GC
1 KSJ99S03-02Q1GC-1
3.0 X 10 5 KSJ99S03-0103GC
1 KSJ99S03-0103GC-1
3.0 X 20 5 KSJ99S03-0203GC
1 KSJ99S03-0203GC-1
4.0 X 10 5 KSJ99S03-0104GC
1 KSJ99S03-0104GC-1
4.0 X 20 5 KSJ99S03-0204GC
1 KSJ99S03-0204GC-1
5 4.0 X 10 5 KSJ99S05-0104GC
1 KSJ99S05-0104GC-1
4.0 X 20 5 KSJ99S05-0204GC
1 KSJ99S05-0204GC-1
10 X 10 2 KSJ99S05-0110CC
20 X 10 2 KSJ99S05-0120CCN
30 X 10 2 KSJ99S05-0130CCN

*When using it for the first time, please purchase the cartridge holder corresponding to size of column.

Cellulose-SZ Cartridge Columns

Particle size
(µm)		 Column size
Inner diameter X length (mm)		 /pack Product Number
3 2.1 X 10 5 KSZ99S03-01Q1GC
1 KSZ99S03-01Q1GC-1
2.1 X 20 5 KSZ99S03-02Q1GC
1 KSZ99S03-02Q1GC-1
3.0 X 10 5 KSZ99S03-0103GC
1 KSZ99S03-0103GC-1
3.0 X 20 5 KSZ99S03-0203GC
1 KSZ99S03-0203GC-1
4.0 X 10 5 KSZ99S03-0104GC
1 KSZ99S03-0104GC-1
4.0 X 20 5 KSZ99S03-0204GC
1 KSZ99S03-0204GC-1
5 4.0 X 10 5 KSZ99S05-0104GC
1 KSZ99S05-0104GC-1
4.0 X 20 5 KSZ99S05-0204GC
1 KSZ99S05-0204GC-1
10 X 10 2 KSZ99S05-0110CC
20 X 10 2 KSZ99S05-0120CCN
30 X 10 2 KSZ99S05-0130CCN

*When using it for the first time, please purchase the cartridge holder corresponding to size of column.

Cartridge Holder

Product Number
Cartridge holder
(Inner diameter: 1.0-4.0 mm)		 length: 10 mm XPGCHP1
length: 20 mm XPGCHP2
Semi-prep Cartridge Holder Inner diameter: 10 mm XPCHSPW1
Inner diameter: 20 mm XPGHFSP20ID
Inner diameter: 30 mm XPGHFSP30ID

Packing Materials

Packing material Particle size
(µm)		 Product number
Amylose-SA 5 KSA99S05
10 KSA99S11
20 KSA99S21
Cellulose-SB 5 KSB99S05
10 KSB99S11
20 KSB99S21
Cellulose-SC 5 KSC99S05
10 KSC99S11
20 KSC99S21
Cellulose-SJ 5 KSJ99S05
10 KSJ99S11
20 KSJ99S21
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