Improving the retention behaviour of hydrophilic compounds on polar stationary phases

Do you analyse hydrophilic compounds? Do you want to improve the retention on polar stationary phases such as PFP or Diol?

In this technical note, two different options for the improved analysis of hydrophilic compounds on YMC-Triart PFP and YMC-Triart Diol-HILIC are shown. The pH value and the amount of organic solvent are examined to learn more about the retention behaviour of basic, acidic and zwitterionic compounds using these phases. Due to their different selectivity, pentafluorophenyl (PFP) or Diol modifications are an ideal choice for the analysis of hydrophilic compounds which often remain unretained or unresolved on conventional C18 phases.

You can download the full method details here.

To get further information about the YMC-Triart series of columns.