Exhibitaion 展覽資訊

AMERICAS

USA

Show name Dates Location
TIDES 20 May. – 23 May., 2019 San Diego, CA
PREP 2019 7 Jul. -10 Jul., 2019 Baltimore, MD
SFC 2019 29 Sep. -1 Oct., 2019 Philadelphia, PA
2019 EAS 18 Nov. -20 Nov., 2019 Princeton, NJ
PITTCON 2020 1 Mar. – 5 Mar., 2020 Chicago, IL

EUROPE

Belgium

Show name Dates Location
Laborama 2019 14 Mar. – 15 Mar., 2019 Brussels

Austria

Show name Dates Location
LAB Supply 19 Mar., 2019 Vienna

Germany

Show name Dates Location
LAB Supply 3 Apr., 2019 Frankfurt-Hoechst
LAB Supply 15 May., 2019 Leverkusen
LAB Supply 13 Jun., 2019 Berlin
LAB Supply 28 Aug., 2019 Dresden
BioTalk Summit 23 Sep. – 24 Sep., 2019 Berlin
LAB Supply 25 Sep., 2019 Münster
LAB Supply 29 Oct., 2019 Hamburg
4. IUTA AnalytikTag 07 Nov., 2019 Duisburg

Italy

Show name Dates Location
HPLC 2019 16 Jun. – 20 Jun., 2019 Milan

ASIA

Korea

Show name Dates Location
The Pharmaceutical Society of Korea 29 Jan., 2019 Daegu
2019 KOREA LAB 16 Apr. – 19 Apr., 2019 Goyang
The Korean Society for Applied Biological Chemistry 20 Jun. – 22 Jun., 2019 Busan
Korean Chemical Society 16 Oct. – 18 Oct., 2019 Changwon
The Korean Society of Pharmacognosy 28 Nov., 2019 Seoul

India

Show name Dates Location
INDIA LAB EXPO 19 Sep. – 21 Sep., 2019 Hyderabad
CPhI india P-mec 26 Nov. – 28 Nov., 2019 Greater Noida

WEBINAR SERIES

mAbs / Peptide / Oligo / ADC Purification & Production Learning Series

 

Webinars from the 2020 Learning Series – on YouTube
Process & economics for continuous purification by MCSGP enabled HPLC (peptides / oligo yield & purity) by Thomas Müller-Späth, Ph.D.
CaptureSMB; How does it work – twin-column capture LPLC technology and practical application by Thomas Müller-Späth, Ph.D.
N-Rich® – Automated process of enriching of side fraction / impurity – a unique isolating technique for QC/QA by Thomas Müller-Späth, Ph.D.
UV-based dynamic process control of twin-column LPLC system (AutomAb) by Thomas Müller-Späth, Ph.D.
Multi-functionality elements of twin-column LPLC systems; Continuous capture, BID, Sequential polish… by Wayne Nettnay
Sequential (orthogonal) polishing chromatography; a “pool-less” process & how it works by Thomas Müller-Späth, Ph.D.
Design features of GMP scale MCSGP enabled HPLC by Dr. Kathleen Mihlbachler and Matt Bui
UV-based dynamic process control of HPLC twin-column MCSGP enabled system (Mcontrol / AutoPeak) by Thomas Müller-Späth, Ph.D.
The Contichrom CUBE bench FPLC tool – features and applications for large and small molecule process development by Thomas Müller-Späth, Ph.D.
Process characterization and validation for continuous chromatography systems by Thomas Müller-Späth, Ph.D.
Virus clearance and carryover study on twin-column (continuous chromatography) system by Thomas Müller-Späth, Ph.D.
Recipes, Reports & Trending tools for TWIN / LPLC’s by Hanna Froebe
Case studies – customer data from CaptureSMB experiences of twin column system by Dr. Kathleen Mihlbachler
Novel benchtop FLPC (Contichrom® CUBE unit) ChromIQ software – unique features for design, operation and evaluation of continuous chromatography by Thomas Müller-Späth, Ph.D.
Automation of twin-column chromatography – insights on how the system controls enable users’ easy operation by Dr. Kathleen Mihlbachler
Single use interface on twin-column systems; hybrid design use in lower classification cleanrooms by Wayne Nettnay
YMC – chromatography analytical to prep scale tools – leveraging YMC technology by Gerard Gach, Jeff Kakaley & Ann Rousek

分離/純化方法開發策略-Strategy of method development for isolation/purification

生產級(Pilot or production scale)/製備型液相層析(Preparative HPLC /MPLC)與實驗室液相層析(HPLC)的分離純化(purification)原理和方法相同,但由於進樣量與層析管柱尺寸大小差異,製備級純化需考慮生產成本並有效收集目標成分(並達到要求規格,例如純度),因此分離純化策略上需與實驗室採取不同的角度來選擇分離條件。

製備級純化方法開發步驟 Steps for preparative purification

1. 分析級條件確認 Method development on the analytical scale

■ 選擇層析分離模式(膠體填料) Separation mode (packing material)

■ 分析條件確認 Separation method

2. 樣品進樣量確認 Loading study

■ 進樣濃度與體積 Concentration Load and Volume Load

■ 進樣量最佳化 Loading amount

■ 檢測條件最佳化 Detection

3. 製程純化放大 Consideration for scaling up

■ 純化放大規模選擇 Selection guide for the preparative scale

■ 管柱純化膠體之粒徑選擇 Selection of the particle size

4. 放大製備純化條件最佳化 Method optimization on the preparative scale

■ 分離條件最佳化 Separation method optimization

■ 選擇合適之分離純化收集系統 Preparative system evaluation

5. 進行樣品純化 Performing preparative separation

製備純化放大之方法說明歡迎來信索取

藉由分析級條件之研究,選擇出管柱尺寸及膠體粒徑。並進行大規模之分離條件。

製備純化放大之方法說明歡迎來信索取